The TRS and TRP groups did not differ in terms of age, sex, or medication-dosage. Of the 86 patients with anxiety disorder, 56 patients (65%) were classified in the TRS group. The theta-beta ratio (TBR) was calculated, and an analysis of covariance was performed. The beta-wave was subdivided into low-beta, beta, and high-beta waves. We obtained the absolute-EEG measurements for 19-channels and analyzed qEEG findings according to the frequency range: delta, theta, alpha, and beta. After 8–12 weeks, the participants were divided into treatment-resistant (TRS) and treatment-response (TRP) groups based on their Clinical Global Impressions-Severity (CGI-S) scores.

A total of 86 patients were diagnosed with anxiety disorder according to the Diagnostic and Statistical Manual of Mental Disorders 5th edition, and subsequently treated with antidepressants. This study aimed to investigate the effectiveness of a quantitative electroencephalography (qEEG) biomarker in predicting the response to pharmacological treatment in patients with anxiety disorder.

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